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Plasma乳酸菌
可直接激活预防病毒感染
免疫系统的“指挥官”！

最近的研究表明，
作为免疫系统“指挥官”的
“浆细胞样树突状细胞（pDC）”
在预防病毒感染方面发挥着重要作用。
预防病毒感染免疫系统“指挥官”
可以检测各种病毒的入侵，
激活人体免疫系统，预防感染。

普通乳酸菌无法激活预防病毒
感染免疫系统的“指挥官”。
然而，麒麟的Plasma乳酸菌
是在世界上首次※1
发现的唯一可直接激活预防病毒感染
免疫系统“指挥官”的乳酸菌。

※1：在已发表的有关乳酸菌的论文中，Plasma乳酸菌是唯一已被证实可直接激活人体内浆细胞样树突状细胞（pDC）的乳酸菌
（截止2019年11月15日，据麒麟控股调查）

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临床试验和非临床试验※2已证实:
Plasma乳酸菌对流感、感冒、
轮状病毒感染和登革热等
的各种病毒具有防御的效果。

※2：感冒、流感的临床试验，轮状病毒感染和登革热的非临床试验的结果。

Plasma乳酸菌
相关论文一览表（临床试验9篇、非临床试验15篇）

  1. Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara D. (2012) Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS One 7: e32588.
  2. Sugimura T, Jounai K, Ohshio K, Tanaka T, Suwa M, Fujiwara D. (2013) Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells. Clin Immunol 149: 509–518.
  3. Jounai K, Sugimura T, Ohshio K, Fujiwara D. (2015) Oral administration of Lactococcus lactis subsp. lactis JCM5805 enhances lung immune response resulting in protection from murine parainfluenza virus infection. PLoS One. 6: e0119055.
  4. Fujii T, Tomita Y, Ikushima S, Horie A, Fujiwara D. (2015) Draft genome sequence of Lactococcus lactis subsp. lactis JCM 5805T, a strain that induces plasmacytoid dendritic cell activation. Genome Announc 3 : e00113-15
  5. Sugimura T, Takahashi H, Jounai K, Ohshio K, Kanayama M, Tazumi K, Tanihata Y, Miura Y, Fujiwara D, Yamamoto N. (2015) Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus. Br J Nutr. 3:1-7.
  6. Suzuki H, Kanayama M, Fujii T, Fujiwara D, Sugimura K（2015）Effects of the beverage containing Lactococcus lactis subsp. lactis JCM5805 on anti‒viral immune responses and maintenance of physical conditions -a randomized, double‒blind, placebo‒controlled, parallel‒group Trial―　Jpn Pharmacol Ther. 43:1465‒72.
  7. Tanaka K, Suzuki H, Kanayama M, Fujii T, Fujiwara D, Nozawa H, Sugimura K.　(2015) The safety evaluation of long‒term or excessive intake of the beverage containing Lactococcus lactis subsp. lactis JCM 5805 and resistant maltodextrin -a randomized, double‒blind, placebo‒controlled, parallel‒group trial―Jpn Pharmacol Ther. 43:1711‒27.
  8. Suzuki H, Ohshio K, Fujiwara D. (2016) Lactococcus lactis subsp. lactis JCM5805 activates natural killer cells via dendritic cells. Biosci Biotec Biochem. 80: 798-800
  9. Shibata T, Kanayama M, Haida M, Fujimoto S, Oroguchi T, Sata K, Mita N, Kutsuzawa T, Ikeuchi M, Kondo M, Naito K, Tsuda M, Nishizaki Y, Ishii N. (2016) Lactococcus lactis JCM5805 activates anti-viral immunity and reduces symptoms of common cold and influenza in healthy adults in a randomized controlled trial. J Func Food. 24: 492-500.
  10. Sakata K, Sasaki Y, Jounai K, Fujii T, Fujiwara D. (2017) Preventive effect of Lactococcus lactis subsp.lactis JCM 5805 yogurt intake on influenza infection among schoolchildren. Health 9: 756-762.
  11. Fujii T,Jounai K, Horie A, Takahashi H, Suzuki H, Oshio K, Fujiwara D, Yamamoto N. (2017) Effects of heat-killed Lactococcus lactis subsp. lactis JCM 5805 on mucosal and systemic immune parameters, and antiviral reactions to influenza virus in healthy adults; A randomized controlled double-blind study. J Func Food. 35: 513-521.
  12. Jounai K, Sugimura T, Morita Y, Ohsio K, Fujiwara D. (2018) Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice. Int Immunopharmacol., 56: 205-211.
  13. Kanayama M, Kato Y, Tsuji T, Konoeda Y, Hashimoto A, Kanauchi O, Fujii T, Fujiwara D. (2018) Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate. Sci Rep., 8: 3147.
  14. Sugimura T, Jounai K, Ohshio K, Suzuki H, Kirisako T, Sugihara Y, Fujiwara D. (2018) Long-term administration of pDC-stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice. Int Immunopharmacol., 58:166-172.
  15. Tsuji R, Komano Y, Ohshio K, Ishii N, Kanauchi O. (2018) Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence. Exp Gerontol., 111: 10-16.
  16. Suzuki H, Jounai K, Ohshio K, Fujii T, Fujiwara D. (2018) Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria enhances antigen-specific immune responses.　Biochem Biophys Res Commun., 503: 1315-1321.
  17. Kato Y, Kanayama M, Yanai S, Nozawa H, Kanauchi O, Suzuki S. (2018) Safety evaluation of excessive intake of Lactococcus lactis subsp. lactis JCM 5805: A randomized, double-blind, placebo-controlled, parallel-group trial. Food Nutr Sci., 9:403-419.
  18. Komano Y, Shimada K, Naito H, Fukao K, Ishihara Y, Fujii T, Kokubo T, Daida H. (2018) Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial. J Int Soc Sports Nutr., 15:39.
  19. Suzuki H, Tsuji R, Sugamata M, Yamamoto N, Yamamoto N, Kanauchi O. (2019) Administration of plasmacytoid dendritic cell stimulative lactic acid bacteria is effective against dengue virus infection in mice. Int J Mol Med., 43:426-434
  20. Tsuji R, Yamamoto N, Yamada S, Fujii T, Yamamoto N, Kanauchi O. (2018) Induction of anti-viral genes mediated by humoral factors upon stimulation with Lactococcus lactis strain Plasma results in repression of dengue virus replication in vitro. Antiviral Res., 160:101-108.
  21. Kokubo T, Komano Y, Tsuji R, Fujiwara D, Fujii T and Kanauchi O. (2019) Plasmacytoid dendritic cell-stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, relieves exercise-induced fatigue and aids recovery via immuno-modulatory action. Int J Sport Nutr Exer Metabol., 5:1-5.
  22. Horie A, Tomita Y, Oshio K, Fujiwara D, Fujii T. (2019) Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells. BMC Microbiol., 19: 88
  23. Tsuji R, Fujii T, Nakamura Y, Yazawa K, Kanauchi O. (2019) Staphylococcus aureus epicutaneous infection is suppressed by Lactococcus lactis strain Plasma via IL-17A elicitation. J Infect Dis., 24. pii: jiz204
  24. Sugimura T, Jounai K, Ohshio K, Fujiwara D. (2019) Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis strain Plasma in mice. Biosci Biotec Biochem., Jul 18:1-4.

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