Effects of L. lactis Plasma

01Anti-aging (non-clinical study)

Inhibits visible aging!

It has been found that intake of L. lactis Plasma suppresses the increase of aging scores. Specifically, close observation of the skin revealed that it suppresses structural collapse due to aging.

Change in Aging Score due to
L. lactis Plasma

Aged! / Staying youthful!

Skin Thickness Comparison

Standard diet/L. lactis Plasma

Source: Int Immunopharmacol. 58: 166-172, 2018.

02Sports Training

Suppresses physical discomfort caused
by strenuous exercise,
and reduces fatigue!

It has been found that intake of
L. lactis Plasma reduces the subjective symptoms of physical discomfort and fatigue during continuous intense exercise.

Accumulated data of subjective symptoms of physical discomfort
and fatigue after exercise

Suppression of physical discomfort
Reduces fatigue

* indicates statistically significant with P<0.05
Source: J Int Soc Sports Nutr. 15: 39, 2018.

03Work Performance

Improved labor-performance
indicators!

It has been confirmed that the intake of L. lactis Plasma resulted in maintenance of good physical comfort and improved work performance indices.

Comparison of effect
on physical comfort due to intake

Maintains good physical comfort**

Comparison of effect
on work performance due to intake

Improved performance

*Self-evaluation of performance on-the-job for the past 28 days
** indicates statistically significant with P<0.01
* indicates statistically significant with P<0.05
Source: Prev Nutr Food Sci. 25(2): 140-145, 2020.

04Increase the skin barrier function

Maintain the balance of your skin flora!

It has been found that intake of L. lactis Plasma
maintains the balance of skin flora and enhances the skin barrier function.
At this time, there was a confirmed increase in tight junction gene* expression, which plays an important
role in skin barrier function.

*Tight junction gene: A gene that produces a protein necessary for skin cells to bond together, which is said to contribute to water retention and other functions.

Effects on skin flora

Placebo No change 85.26% Change 14.74% / L. lactis Plasma No change 99.48% Change 0.51%

Source: 117th Annual Meeting of the Japan
Dermatological Association

Comparison of tight junction gene
expression levels

Placebo / L. lactis Plasma
Tight Junction Component Gene A / Increased Expression**
Tight Junction Component Gene B Increased Expression*

* indicates statistically significant with P<0.05
Source: 117th Annual Meeting of the Japan
Dermatological Association

What is skin flora?

Skin flora is the bacterial population on our skin surface. Intestinal flora has been the focus of much attention in recent years, but flora exists not only in the intestines but also on the skin. When this balance is good and stable, skin health is easily to maintain. The types of bacteria include "good bacteria", "opportunistic bacteria", and "bad bacteria", and there are between 1 and 10 million bacteria per square centimeter of your skin.

Doing helpful work - Good bacteria Staphylococcus epidermidis, etc. / Taking advantage of weakness - Opportunistic bacteria Acne bacteria, etc. / Doing harmful work - Bad bacteria Staphylococcus aureus, etc.

Source: Nat. Rev. Microbiol. (2011)
Society of Cosmetic Chemists of Japan (SCCJ) Encyclopedia of Cosmetics

05Effect similar to vaccine adjuvant
[enhancement effects]
(non-clinical study)

Improved immune efficiency against
influenza antigens

The intake of L. lactis Plasma increased the immune efficiency, suggesting an effect similar to a vaccine adjuvant.

Comparison of the amount of antibodies responding to influenza antigens

Antigen-specific antibody amount

* indicates statistically significant with P<0.05
Source: Biochem Biophys Res Commun.
503: 1315-1321, 2018.

What is a vaccine adjuvant?

Adjuvants, the name of which is derived from the Latin word "adjuvare" meaning "to help", are substances that are administered with vaccines to increase their effectiveness ("immunogenicity"). Since the adjuvant is only intended to enhance the efficacy of the vaccine, administering the adjuvant alone will not produce a vaccine effect. Vaccines with purified partial components of the antigens are generally less effective and require the addition of an adjuvant.

Source: Vaccine Adjuvant Research Center
https://www.nibiohn.go.jp/CVAR/adjuvant.html